Wake Forest vs. Clemson odds, line: 2022 college basketball picks, Feb. 23 predictions from proven model

An ACC battle is on tap between the Wake Forest Demon Deacons and the Clemson Tigers at 7 p.m. ET on Wednesday at Littlejohn Coliseum. Clemson is 12-15 overall and 8-5 at home, while Wake Forest is 21-7 overall and 5-4 on the road. Wake Forest bounced back from a two-game losing streak with a win over Notre Dame on Saturday. 

The Demon Deacons are favored by 2.5 points in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over-under is set at 144.5. Before entering any Wake Forest vs. Clemson picks, you’ll want to see the college basketball predictions from the model at SportsLine.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Wake Forest. You can head to SportsLine to see its picks. Here are several college basketball odds for Clemson vs. Wake Forest:

• Clemson vs. Wake Forest spread: Clemson +2.5
• Clemson vs. Wake Forest over-under: 144.5 points

What you need to know about Clemson

Clemson has lost six straight games since picking up a win over Florida State earlier this month. The Tigers are returning home after consecutive road losses at FSU and Louisville. Leading scorer PJ Hall hurt his left foot after playing less than two minutes on Saturday and did not return. 

Hall, who is also the team’s second-leading rebounder, is questionable for Wednesday’s contest. Al-Amir Dawes came off the bench to score a game-high 18 points against Louisville. Clemson has won eight straight home games against Wake Forest, and the Tigers also blew out the Demon Deacons on the road last season. 

What you need to know about Wake Forest

Wake Forest was able to avoid its first three-game losing streak of the season when it rallied from a six-point halftime deficit in a 79-74 win over Notre Dame. Leading scorer Alondes Williams had 23 points, including 11 in the final eight minutes of the game. He is the ACC’s top scorer, averaging 19.9 points per contest. 

Williams also leads Wake Forest in rebounding (6.9) and assists (5.1). Junior forward Jake LaRavia is averaging 14.8 points and 6.7 rebounds per game. The Demon Deacons have covered the spread in eight of their last 11 games, including five of their last six road games. 

How to make Wake Forest vs. Clemson picks

The model has simulated Clemson vs. Wake Forest 10,000 times and the results are in. We can tell you that the model is leaning over, and it’s also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Wake Forest vs. Clemson? And which side of the spread covers over 60 percent of the time? Visit SportsLine now to find out, all from the model that has crushed its college basketball picks.