Thursday Night Football odds, spread, line: Titans vs. 49ers prediction, NFL picks from expert who’s 21-10

After squandering a 10-point lead and having their three-game winning streak snapped at Seattle in Week 13, the San Francisco 49ers allowed a 14-point advantage slip away in the fourth quarter at Cincinnati and fell behind in overtime before pulling out a 26-23 victory. They had an easier time of it at home against Atlanta last week, taking control in the second half en route to a 31-13 triumph. San Francisco (8-6) aims for its sixth win in seven games when it visits the AFC South-leading Tennessee Titans (9-5) on Thursday Night Football.

Kickoff from Nissan Stadium in Nashville, Tenn., is scheduled for 8:20 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Titans odds at Caesars Sportsbook, while the over-under for total points scored is 44.5. Before locking in any Titans vs. 49ers picks or NFL predictions, make sure you check out what SportsLine expert Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2021 campaign, Hartstein was 351-291 all-time on NFL sides, returning more than $2,200 for $100 bettors.

In addition, Hartstein is an expert on the Titans. He is a blistering 21-10-1 in his last 32 against-the-spread picks involving Tennessee, returning more than $1,000 for $100 bettors. Anyone who has followed him is way up.

Now, Hartstein has locked in on 49ers vs. Titans from every angle and released a confident against-the-spread pick. You can visit SportsLine now to see his TNF picks. Here are several NFL odds and betting lines for Titans vs. 49ers:

• Titans vs. 49ers spread: San Francisco -3
• Titans vs. 49ers over-under: 44.5 points 
• Titans vs. 49ers money line: San Francisco -170, Tennessee +145
• SF: 49ers are 5-1 against the spread in their last six games 
• TEN: Titans are 7-1-1 ATS in their last nine meetings with San Francisco

Why the 49ers can cover

San Francisco is one of a dozen NFL teams with a point differential of plus-46 or better this season and has reached double digits in each of its first 14 games. Since being limited to 17 points by Arizona in Week 9, the 49ers have scored at least 23 in six straight contests — producing 30 or more four times in that span. Jimmy Garoppolo has thrown 12 touchdown passes this year over his last seven games after tossing only six in his first six outings.

Deebo Samuel continues to be a dual threat for San Francisco. The 25-year-old wideout ranks in the top 10 in receiving yards as he’s already posted the first 1,000-yard season (1,088) of his three-year career. In addition to his five touchdown catches, Samuel leads the 49ers with seven rushing scores and is second on the team with 269 yards on the ground.

Why the Titans can cover

Tennessee also suffered a major loss in the backfield this season as 2020 NFL rushing leader Derrick Henry fractured his foot on Oct. 31 after running for 937 yards and 10 touchdowns in eight games. Henry’s absence was felt immediately, as the Titans failed to have a player gain more than 40 yards on the ground in the first three games without their star. But they have had three 100-yard performances over their last three outings and still rank among the league’s best in rushing this year at 142.3 yards per game. 

Dontrell Hilliard and D’Onta Foreman both reached triple-digit rushing yards during Tennessee’s loss at New England in Week 12, with the former gaining 131 and the latter 109. It was the first career 100-yard effort for both players, and Foreman came up with another in Sunday’s 19-13 setback at Pittsburgh, carrying 22 times for 108 yards. Quarterback Ryan Tannehill has recorded a rushing TD in four of the last six games and ranks second on the team with seven.

How to make Titans vs. 49ers picks

For Thursday Night Football, Hartstein is leaning Over on the point total, but he also says a critical X-factor makes one side of the spread a must-back. He’s only sharing what it is and which side of the Titans vs. 49ers spread to back at SportsLine.

So who wins 49ers vs. Titans on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the 49ers vs. Titans spread you should jump on, all from the NFL expert who’s an amazing 21-10 on picks involving Tennessee, and find out.